The way in which nuclear licensees’ organisations are structured and resourced clearly has a potential impact on nuclear safety. As experience has continually demonstrated, operating organisations with a strong training programme for personnel, adequate resourcing and overall effective leadership and management perform more effectively in times of crisis than those lacking in one or more of these areas. In parallel, the nuclear industry is developing new resource deployment strategies which are making increased use of contractors and leading to changes in organisational structure, which in turn create challenges for the continued safe operation of nuclear facilities. This technical opinion paper represents the consensus among human and organisational factor specialists in NEA member and associated countries on the methods, approaches and good practices to be followed in designing an organisation with a strong safety focus while meeting business needs. It also considers some of the attributes that an organisation which is effectively managing its resources and capabilities might demonstrate.