The main purpose of this status report is to increase awareness and understanding of the potential applications of indicators in the safety case, and provide support for further development in the area. It is intended to be useful to anyone engaged in the planning, preparation and review of safety cases for radioactive waste repositories. It is, however, focussed on providing advice to developers of deep geological repositories with programmes at an early stage of development (e.g. pre-site selection), rather than those that are more mature and which have already defined their assessment methodologies and end-points. This report may also be useful to regulators and those engaged in peer review of safety assessments, particularly in regimes where regulators may choose to stipulate the use of specific indicators in addition to dose or risk in formal safety cases that are submitted to them.